Brain mechanisms in health and disease

The complexity and inaccessibility of the brain has often made it difficult to find cause and consequence in our aim to understand how our brain works and what goes wrong in brain disorders. To change this situation, we need to invest in new mechanistic research aimed to find cause and consequence in the developmental processes and processes in the adult that orchestrate and modulate brain functions. To be successful, we need to overcome the challenges inherent in modeling the complexity of the human brain experimentally and integrate knowledge across levels of complexity, from molecules to the whole brain. Recent advances in this field, for instance in stem cell biology, proteomics, genomics, (opto-)physiology, live cell imaging and environmental factors that lastingly influence brain development, provide a very strong basis to be more successful in the coming decade. Projects aimed at model systems and concepts that recapitulate aspects of the human brain and/or brain disease are specifically promoted. Both experimental animal and human brain studies are eligible.